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2-Amino-5-chloropyridine (2ACPD) has been reported to suppress experimental allergic encephalomyelitis (EAE) in Lewis rats and prevent the induction of EAE in SJL/J mice. To further evaluate the role of 2ACPD and thus its possible therapeutic use in multiple sclerosis, the effects of 2ACPD on the induction and clinical development of EAN were examined in Lewis rats. The results revealed that 2ACPD given at doses of 20 to 100 mg/kg p.o. significantly delayed the onset and reduced the incidence of clinical EAN when administered for 7-10 days following immunization. In addition, 2ACPD given 3 times a week at 10 mg/kg for 14 days following immunization also delayed the development of clinical EAN. This protective effect of 2ACPD was shown to be dose dependent, with a reduction in EAN observed at 20 mg/kg while maximal protection was seen with doses of 40 mg/kg or greater. Also, 2ACPD given at a dose of 10 mg/kg with or without a 7 day interval between treatments was effective in delaying the onset and reducing the incidence of the disease. Daily oral administration of 2ACPD at the dose of 40 mg/kg for 10 days after immunization was not effective in significantly inhibiting the development of EAN. These results demonstrate that 2ACPD can effectively inhibit
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