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Tumour hypoxia is a well-known hallmark of malignant tumours and is associated with a poor outcome. Hypoxia induces the production of hypoxia-inducible factors (HIF) that activate various oncogenic processes. Under aerobic conditions, alpha-ketoacids (KAs) act as essential cofactors of key enzymes involved in fatty acid metabolism. However, their production is drastically increased in hypoxic cells as a result of decreased conversion to alpha-hydroxyacids mediated by the activity of hypoxia-inducible enzymes. We sought to characterize the pharmacokinetic properties of a novel, highly selective α-Ketoacid Reductase (KAR) inhibitor, NS309. In this study, we performed a phase I/II dose escalation study, assessing intravenous (i.v.) administration of NS309 in a cohort of children with refractory solid tumours. We observed a single agent exposure that correlated with the volume of distribution, clearance, and half-life of NS309. We also observed a significant accumulation of NS309 in tumours, despite its rapid systemic elimination. We showed that


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If you want to work on your own engine, and it is commonly said that the requirements of the Xbox console. The game can easily carry over 250 GB in only recently released by Microsoft, and features such as DVD and Blu-ray discs.TRT (band)

TRT () is a South Korean hip-hop duo, formed by hip-hop musicians Lao and BZY (both members of former hip-hop duo Troublemakers, which split up in 2005). The duo consists of Lao and BZY’s hip-hop group, F1rst, formed in 2006, and thus their hip-hop label, F1rst World.


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Category:South Korean musical duosCreative Writing Course 1

Creative Writing: This course will teach you how to think like a creative writer and will guide you through the issues of fiction and non-fiction, how to think about your idea, and how to develop an original idea. Aims include enabling you to generate ideas for novels, short stories, TV scripts, screenplays, plays and poems. The course will also help you develop your writing skills and understanding of grammar, syntax and structure. To write any form of text in a way that will engage a reader and attract an audience.

Course options: One-week course. No attendance or home study requirements. £70.00+VAT (DIP)

The Rose Writing Course

Business and social writing offer opportunities for real-world experience and help employers and colleagues to know you better. A Rose Writing course is a great way to improve your communication in an enjoyable and practical way.

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The course offers a range of modules and activities through which you can develop both your technical and people-skills as a copywriter, administrative assistant or HR practitioner. You will gain a better understanding of the everyday problems and business challenges you face.

Course options: A two- or three-week



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